Publication:
Neuroprotective effects of combined administration of coenzyme Q10 and vitamin-E in chronic celebral hypoperfusion-induced neurodegeneration in rats

dc.contributor.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#en_US
dc.contributor.authorAzimi, Mahmoodullahen_US
dc.date.accessioned2024-10-09T04:36:54Z
dc.date.available2024-10-09T04:36:54Z
dc.date.issued2019
dc.description.abstractAlzheimer’s disease (AD) is the most common type of neurodegenerative diseases and the leading cause of dementia in the elderly. The number of people with neurodegenerative diseases is massively increasing. Currently, there is no prevention, cure or drugs to slow down the progression of AD. Numerous evidences have revealed the presence of oxidative stress in the beginning and progression of AD. Therefore, the potential of using natural antioxidants for prevention and treatment of AD has attracted considerable attention. Coenzyme Q10 (CoQ10) and vitamin E (Vit E) have been reported as powerful antioxidants and used as protective agents for various illnesses. In spite of significant results in experimental studies, which used single antioxidant in AD models, clinical trials have failed to recapitulate the promising outcomes documented in animal studies. Therefore, an efficient strategy would be the use of combination of antioxidants in the treatment of Alzheimer’s disease to provide synergetic effects and enough antioxidant action without the need for large and toxic doses of single antioxidants. This study assessed the neuroprotective effects of combination of CoQ10 with vitamin E in Chronic Cerebral Hypoperfusion-induced neurodegeneration (CCH-ND) rat model. After acclimatization, 27 Sprague Dawley rats weighing 200-250 g were divided into six groups. Group A – sham control, Group B – 2VO, group C – 2VO+E (treated daily with Vit E, 100 mg/kg, orally following 2VO) Group D CoQ10 (treated daily with CoQ10, 200 mg/kg, orally following 2VO), group E- CoQ10+E (treated with combination of CoQ10 and Vit E) and group F treated with coconut oil as vehicle. On the 8th week, all the rats were tested by Morris water maze cognitive test and then euthanized and the hippocampi were isolated. Viable neuronal cell count in the hippocampal region was estimated. The Isoprostane F2 (F2-IsoPs) levels were assessed in the brain homogenates to quantify the oxidative stress status. There was significant difference in neuronal cell death, memory and learning, and F2-Iso level in untreated 2VO group compared to the treated and sham groups. However, there was no statistically significant difference in neuroprotective effects of combination of vitamin E with CoQ10 and each one alone. To conclude, combination of antioxidants (Vit E and CoQ10) improve memory, neuronal cell viability and decrease antioxidant level, same as using each one alone and sham operated group in animal models of CCH.en_US
dc.description.degreelevelMasteren_US
dc.description.identifierThesis : Neuroprotective effects of combined administration of coenzyme Q10 and vitamin-E in chronic celebral hypoperfusion-induced neurodegeneration in rats /by Mahmoodullah Azimien_US
dc.description.identityt11100405345Mahmoodullahen_US
dc.description.kulliyahKulliyyah of Medicineen_US
dc.description.notesThesis (MMDSC)--International Islamic University Malaysia, 2019.en_US
dc.description.physicaldescriptionxv, 76 leaves :colour illustrations ;30cm.en_US
dc.description.programmeMaster of Medical Sciencesen_US
dc.identifier.urihttps://studentrepo.iium.edu.my/handle/123456789/10843
dc.identifier.urlhttps://lib.iium.edu.my/mom/services/mom/document/getFile/pUw6DAS6rnit4Db3Aoz82g7OtGN8ExA620200117152516504
dc.language.isoenen_US
dc.publisherKuantan, Pahang :International Islamic University Malaysia,2019en_US
dc.rightsCopyright International Islamic University Malaysia
dc.titleNeuroprotective effects of combined administration of coenzyme Q10 and vitamin-E in chronic celebral hypoperfusion-induced neurodegeneration in ratsen_US
dc.typeMaster Thesisen_US
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
t11100405345Mahmoodullah_SEC_24.pdf
Size:
692.95 KB
Format:
Adobe Portable Document Format
Description:
24 pages file
Loading...
Thumbnail Image
Name:
t11100405345Mahmoodullah_SEC.pdf
Size:
2.9 MB
Format:
Adobe Portable Document Format
Description:
Full text secured file

Collections