Publication:
Immunohistochemical study of leptin receptors in hippocampus of rats with hypoperfusion-induced neurodegeneration

dc.contributor.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#en_US
dc.contributor.authorNor Hazirah binti Abidinen_US
dc.date.accessioned2024-10-09T04:36:40Z
dc.date.available2024-10-09T04:36:40Z
dc.date.issued2018
dc.description.abstractLonger life expectancy leads to shifting in age-related diseases such as dementia and Alzheimer`s disease (AD). The main area affected in AD is the hippocampus, where memory and cognitive processing occurs. Persistent moderate disturbance in cerebral blood flow contributes to dementia and AD. The model involved to induce cerebral hypoperfusion is known as chronic bilateral common carotid arteries ligation, which is also known as 2-vessel occlusion (2VO). Leptin is known to aid memory processing. The main aim in this study was to investigate leptin receptor in hippocampus of rats with hypoperfusion-induced neurodegeneration by using immunohistochemistry, and to study the serum leptin level in animals with the same procedure using enzyme-linked immunosorbent assay (ELISA). The rats were divided into 3 groups: 4 weeks, 6 weeks, and 8 weeks post-2VO. There was no change in serum leptin levels post 2VO procedure. However, there was significant reduction in leptin receptor-immunoreactivity in CA1 of hippocampus after 2VO in time-dependent manner. The reduction in leptin receptor could explain the loss of neuroprotective effect on neurons as well as impairment of the activation of the memory pathway in the hippocampus.en_US
dc.description.degreelevelMasteren_US
dc.description.identifierThesis : Immunohistochemical study of leptin receptors in hippocampus of rats with hypoperfusion-induced neurodegeneration /by Nor Hazirah binti Abidinen_US
dc.description.identityt11100404669NorHazirahAbidinen_US
dc.description.kulliyahKulliyyah of Medicineen_US
dc.description.notesThesis (MMDSC)--International Islamic University Malaysia, 2018.en_US
dc.description.physicaldescriptionxiv, 81 leaves :colour illustrations ;30cm.en_US
dc.description.programmeMaster of Medical Sciencesen_US
dc.identifier.urihttps://studentrepo.iium.edu.my/handle/123456789/10823
dc.identifier.urlhttps://lib.iium.edu.my/mom/services/mom/document/getFile/z3ECcXCKHMEuelNEil23kwADqa33A6op20190905112015512
dc.language.isoenen_US
dc.publisherKuantan, Pahang :International Islamic University Malaysia,2018en_US
dc.rightsCopyright International Islamic University Malaysia
dc.titleImmunohistochemical study of leptin receptors in hippocampus of rats with hypoperfusion-induced neurodegenerationen_US
dc.typeMaster Thesisen_US
dspace.entity.typePublication

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