Publication:
B2 adrenergic receptor gene polymorphisms in hypertensive patients

dc.contributor.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#en_US
dc.contributor.authorM.Atia, Ahmed Elbadrien_US
dc.date.accessioned2024-10-09T04:35:58Z
dc.date.available2024-10-09T04:35:58Z
dc.date.issued2010
dc.description.abstractBackground: Polymorphisms within Beta2-adrenergic receptor (β2AR) gene have been repeatedly linked to hypertension. Among the β2AR polymorphisms detected, Arg16Gly and Gln27Glu codons were considered the two most important variations. Arg16Gly especially, has been found to be significantly associated with hypertension in Caucasian and Black subjects. The amino acid substitution at this codon may lead to abnormal regulation of β2AR activity. The aim of the present study was to assess the association between β2AR polymorphisms and hypertension. Methods: This casecontrol study consisted of 100 unrelated subjects (50 hypertensive and 50 matched normal controls). Arg16Gly and the Gln27Glu polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay. Results: There were no significant evidence of association in allelic and genotypes distribution of Arg16Gly and Glu27Gln with hypertension. Conclusion: These findings suggest that the variation within codon 16 and 27 of β2AR gene were unlikely to confer genetic susceptibility for hypertension in our population samples. Key words: β2-adrenergic receptor, single nucleated polymorphism, hypertension.en_US
dc.description.callnumbert RC 685 H8 M433B 2010en_US
dc.description.degreelevelMaster
dc.description.identifierThesis : B2 adrenergic receptor gene polymorphisms in hypertensive patients /by Ahmed Elbadri M.Atiaen_US
dc.description.identityt00011204521AhmedElbadrien_US
dc.description.kulliyahKulliyyah of Medicineen_US
dc.description.notesThesis (MMDSC)--International Islamic University Malaysia, 2011en_US
dc.description.physicaldescriptionxiii, 55 leaves : ill. ; 30cmen_US
dc.description.programmeMaster of Medical Sciencesen_US
dc.identifier.urihttps://studentrepo.iium.edu.my/handle/123456789/10746
dc.identifier.urlhttps://lib.iium.edu.my/mom/services/mom/document/getFile/I3xzLn9XbNSUxEU9XFBUJXv06RAdfDzo20121003122307206
dc.language.isoenen_US
dc.publisherGombak, Selangor :Kulliyyah of Medicine, International Islamic University Malaysia, 2010en_US
dc.rightsCopyright International Islamic University Malaysia
dc.subject.lcshHypertensionen_US
dc.subject.lcshAdrenaline -- Receptorsen_US
dc.subject.lcshGenetic polymorphismsen_US
dc.titleB2 adrenergic receptor gene polymorphisms in hypertensive patientsen_US
dc.typeMaster Thesisen_US
dspace.entity.typePublication

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